TY - JOUR AU - Ming, Yu AU - Zecevic, Aleksandra A. AU - Hunter, Susan W. AU - Miao, Wenxin AU - Tirona, Rommel G. PY - 2021/09/02 Y2 - 2024/03/28 TI - Medication Review in Preventing Older Adults’ Fall-Related Injury: a Systematic Review & Meta-Analysis JF - Canadian Geriatrics Journal JA - Can Geriatr J VL - 24 IS - 3 SE - Systematic Reviews/Meta-analysis DO - 10.5770/cgj.24.478 UR - https://cgjonline.ca/index.php/cgj/article/view/478 SP - 237-250 AB - <p><strong>Background </strong></p><p>Medication review is essential in managing adverse drug reactions and improving drug safety in older adults. This systematic review evaluated medication review’s role as a single intervention or combined with other interventions in preventing fall-related injuries in older adults.</p><p><strong>Methods </strong></p><p>Electronic databases search was conducted in PubMed, EMBASE, Scopus, and CINAHL. Two reviewers screened titles and abstracts, reviewed full texts, and performed data extraction and risk of bias assessment. Meta-analyses were conducted on studies with similar participants, interventions, outcomes or settings.</p><p><strong>Results </strong></p><p>Fourteen randomized, controlled studies were included. The pooled results indicated that medication review as a stand-alone intervention was effective in preventing fall-related injuries in community-dwelling older adults (Risk Difference [RD] = -0.06, 95% CI: [-0.11, -0.00], I2 = 61%, <em>p </em>= .04). Medication review also had a positive impact on decreasing the risk of fall-related fractures (RD = -0.02, 95% CI: [-0.04, -0.01], I2 = 0%, <em>p </em>= .01).</p><p><strong>Discussion </strong></p><p>This systematic review and meta-analysis has demonstrated that medication review is effective in preventing fall-related injuries in general, and fractures specifically, in community-dwelling older adults. Future investigations focusing on the process of performing medication review will further inform fall-related injury prevention for older adults.</p> ER -