Psychosocial Risk Factors for Cognitive Decline in Late-Life Depression: Findings from the MTLD-III Study

Authors

  • Soham Rej McGill University
  • Amy Begley University of Pittsburgh
  • Ariel Gildengers University of Pittsburgh
  • Mary Amanda Dew University of Pittsburgh
  • Charles F. Reynolds III University of Pittsburgh
  • Meryl A. Butters University of Pittsburgh

DOI:

https://doi.org/10.5770/cgj.18.134

Keywords:

psychosocial risk factors, late-life depression, cognition, dementia, mild cognitive impairment, medical illness burden

Abstract

Background

Cognitive impairment and depression frequently co-occur in late life. There remains a need to better characterize psychosocial risk factors of cognitive decline in older adults with depression. We hypothesized that certain psychosocial factors would be associated with higher risk of cognitive decline in individuals with late-life depression.

Methods

130 individuals aged ≥ 65 years who had achieved remission from a major depressive episode were randomized to donepezil or placebo and then closely followed for two years. Using Cox proportional hazard models, we examined the association between baseline median household income, education level, race, marital status, and social support and cognitive decline over the follow-up.

Results

Lower interpersonal support (OR = 0.86 [0.74-0.99], p = .04) and lower baseline global neuropsychological score (OR = 0.56 [0.36-0.87], p = .001) predicted shorter time to conversion to MCI or dementia in univariate models. These exposures did not remain significant in multivariate analyses. Neither socioeconomic status nor other psychosocial factors independently predicted cognitive diagnostic conversion (p > .05).

Conclusions

We did not find reliable associations between cognitive outcome and any of the psychosocial factors examined. Future largescale, epidemiological studies, ideally using well-validated subjective measures, should better characterize psychosocial risk factors for cognitive decline in late-life depression.

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Published

2015-04-21

How to Cite

1.
Rej S, Begley A, Gildengers A, Dew MA, Reynolds III CF, Butters MA. Psychosocial Risk Factors for Cognitive Decline in Late-Life Depression: Findings from the MTLD-III Study. Can Geriatr J [Internet]. 2015 Apr. 21 [cited 2024 Nov. 22];18(2):43-50. Available from: https://cgjonline.ca/index.php/cgj/article/view/134

Issue

Section

Original Research