Medication Review in Preventing Older Adults’ Fall-Related Injury: a Systematic Review & Meta-Analysis

  • Yu Ming Western University
  • Aleksandra A. Zecevic Western University
  • Susan W. Hunter Western University
  • Wenxin Miao Western University
  • Rommel G. Tirona Western University
Keywords: medication review, falls, fall-related injuries, prevention, older adults



Medication review is essential in managing adverse drug reactions and improving drug safety in older adults. This systematic review evaluated medication review’s role as a single intervention or combined with other interventions in preventing fall-related injuries in older adults.


Electronic databases search was conducted in PubMed, EMBASE, Scopus, and CINAHL. Two reviewers screened titles and abstracts, reviewed full texts, and performed data extraction and risk of bias assessment. Meta-analyses were conducted on studies with similar participants, interventions, outcomes or settings.


Fourteen randomized, controlled studies were included. The pooled results indicated that medication review as a stand-alone intervention was effective in preventing fall-related injuries in community-dwelling older adults (Risk Difference [RD] = -0.06, 95% CI: [-0.11, -0.00], I2 = 61%, p = .04). Medication review also had a positive impact on decreasing the risk of fall-related fractures (RD = -0.02, 95% CI: [-0.04, -0.01], I2 = 0%, p = .01).


This systematic review and meta-analysis has demonstrated that medication review is effective in preventing fall-related injuries in general, and fractures specifically, in community-dwelling older adults. Future investigations focusing on the process of performing medication review will further inform fall-related injury prevention for older adults.

Author Biographies

Yu Ming, Western University

Health and Rehabilitation Sciences, School of Health Studies

Aleksandra A. Zecevic, Western University

School of Health Studies

Susan W. Hunter, Western University

School of Physical Therapy

Wenxin Miao, Western University

School of Information and Media Studies

Rommel G. Tirona, Western University

School of Physiology and Pharmacology

How to Cite
Ming, Y., Zecevic, A. A., Hunter, S. W., Miao, W., & Tirona, R. G. (2021). Medication Review in Preventing Older Adults’ Fall-Related Injury: a Systematic Review & Meta-Analysis. Canadian Geriatrics Journal, 24(3), 237-250.
Systematic Reviews/Meta-analysis