Medication Review in Preventing Older Adults’ Fall-Related Injury: a Systematic Review & Meta-Analysis

Authors

  • Yu Ming Western University
  • Aleksandra A. Zecevic Western University
  • Susan W. Hunter Western University
  • Wenxin Miao Western University
  • Rommel G. Tirona Western University

DOI:

https://doi.org/10.5770/cgj.24.478

Keywords:

medication review, falls, fall-related injuries, prevention, older adults

Abstract

Background

Medication review is essential in managing adverse drug reactions and improving drug safety in older adults. This systematic review evaluated medication review’s role as a single intervention or combined with other interventions in preventing fall-related injuries in older adults.

Methods

Electronic databases search was conducted in PubMed, EMBASE, Scopus, and CINAHL. Two reviewers screened titles and abstracts, reviewed full texts, and performed data extraction and risk of bias assessment. Meta-analyses were conducted on studies with similar participants, interventions, outcomes or settings.

Results

Fourteen randomized, controlled studies were included. The pooled results indicated that medication review as a stand-alone intervention was effective in preventing fall-related injuries in community-dwelling older adults (Risk Difference [RD] = -0.06, 95% CI: [-0.11, -0.00], I2 = 61%, p = .04). Medication review also had a positive impact on decreasing the risk of fall-related fractures (RD = -0.02, 95% CI: [-0.04, -0.01], I2 = 0%, p = .01).

Discussion

This systematic review and meta-analysis has demonstrated that medication review is effective in preventing fall-related injuries in general, and fractures specifically, in community-dwelling older adults. Future investigations focusing on the process of performing medication review will further inform fall-related injury prevention for older adults.

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Published

2021-09-02

How to Cite

1.
Ming Y, Zecevic AA, Hunter SW, Miao W, Tirona RG. Medication Review in Preventing Older Adults’ Fall-Related Injury: a Systematic Review & Meta-Analysis. Can Geri J [Internet]. 2021 Sep. 2 [cited 2021 Oct. 26];24(3):237-50. Available from: https://cgjonline.ca/index.php/cgj/article/view/478

Issue

Section

Systematic Reviews/Meta-analysis