Dementia Risk Prediction in a Longitudinal Geriatric Parkinson’s Disease Cohort: Evaluation and Application of the Montreal Parkinson Risk of Dementia Scale

Authors

  • Linzy Bohn University of Alberta
  • G. Peggy McFall University of Alberta
  • Myrlene Gee University of Alberta
  • Ronald B. Postuma McGill University
  • Roger A. Dixon University of Alberta
  • Richard Camicioli University of Alberta

DOI:

https://doi.org/10.5770/cgj.26.617

Keywords:

Parkinson’s disease, Incipient dementia, Longitudinal change, Risk factors, Montreal Parkinson Risk of Dementia Scale (MoPaRDS)

Abstract

Background

Parkinson’s disease (PD) increases risk for dementia and cascading adverse outcomes. The eight-item Montreal Parkinson Risk of Dementia Scale (MoPaRDS) is a rapid, in-office dementia screening tool. We examine predictive validity and other characteristics of the MoPaRDS in a geriatric PD cohort by testing a series of alternative versions and modelling risk score change trajectories.

Methods

Participants were 48 initially non-demented PD patients (Mage = 71.6 years, range = 65–84) from a three-year, three-wave prospective Canadian cohort study. A dementia diagnosis at Wave 3 was used to stratify two baseline groups: PD with Incipient Dementia (PDID) and PD with No Dementia (PDND). We aimed to predict dementia three years prior to diagnosis using baseline data for eight indicators that harmon-ized with the original report, plus education.

Results

Three MoPaRDS items (age, orthostatic hypotension, mild cognitive impairment [MCI]) discriminated the groups both independently and as a composite three-item scale (area under the curve [AUC] = 0.88). The eight-item MoPaRDS reliably discriminated PDID from PDND (AUC = 0.81). Education did not improve predictive validity (AUC = 0.77). Performance of the eight-item MoPaRDS varied across sex (AUCfemales = 0.91; AUCmales = 0.74), whereas the three-item configuration did not (AUCfemales = 0.88; AUCmales = 0.91). Risk scores of both configurations increased over time.

Conclusions

We report new data on the application of the MoPaRDS as a dementia prediction tool for a geriatric PD cohort. Results support the viability of the full MoPaRDS, and indicate that an empirically determined brief version is a promising complement.

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Published

2023-03-02

How to Cite

1.
Bohn L, McFall GP, Gee M, Postuma RB, Dixon RA, Camicioli R. Dementia Risk Prediction in a Longitudinal Geriatric Parkinson’s Disease Cohort: Evaluation and Application of the Montreal Parkinson Risk of Dementia Scale. Can Geriatr J [Internet]. 2023 Mar. 2 [cited 2024 Feb. 23];26(1):176-8. Available from: https://cgjonline.ca/index.php/cgj/article/view/617

Issue

Section

Original Research