Responsiveness of the QUALID to Improved Neuropsychiatric Symptoms in Patients with Alzheimer’s Disease

Authors

  • Hadas Benhabib Sunnybrook Health Sciences Centre
  • Krista L. Lanctôt Sunnybrook Health Sciences Centre, University of Toronto
  • Goran M. Eryavec North York General Hospital, University of Toronto
  • Abby Li Sunnybrook Health Sciences Centre
  • Nathan Herrmann Sunnybrook Health Sciences Centre, University of Toronto

DOI:

https://doi.org/10.5770/cgj.16.78

Keywords:

QUALID, quality of life, dementia

Abstract

Background

This study aimed to determine whether the Quality of Life in Late-Stage Dementia (QUALID) scale is responsive to changes in behaviour due to therapeutic intervention.

Method

31 long-term care residents with moderate to severe AD and agitation/aggression entered a three-month, open-label trial of memantine 10 mg BID. The relationships between the QUALID and BPSD, global improvement, and cognition at baseline and endpoint, as well as the changes in these scales as a result of treatment, were examined.

Results

Despite a significant improvement in agitation and aggression (NPI agitation, F3,90 = 3.721, p =.014; CMAI total, F3,90 = 6.301, p =.001) and overall behaviour (NPI total, F3,90 = 4.035, p =.010), there was no significant change in QUALID score (t30 =-0.278, p =.783). The QUALID was correlated with NPI at baseline (τ = 0.270, p =.037) and endpoint (τ = 0.404, p =.002), but change scores were not correlated (τ = 0.107, p =.412).

Conclusion

While the QUALID correlates with behavioural measures at single time points, it does not appear to correlate with changes longitudinally associated with treatment.

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Published

2013-09-27

How to Cite

1.
Benhabib H, Lanctôt KL, Eryavec GM, Li A, Herrmann N. Responsiveness of the QUALID to Improved Neuropsychiatric Symptoms in Patients with Alzheimer’s Disease. Can Geriatr J [Internet]. 2013 Sep. 27 [cited 2022 Jun. 28];16(4):180-5. Available from: https://cgjonline.ca/index.php/cgj/article/view/78

Issue

Section

Original Research