Hypovitaminosis D in Delirium: a Retrospective Cross-sectional Study

Authors

  • Jennifer Ford McMaster University
  • Ana Hategan McMaster University, St. Joseph’s Healthcare Hamilton
  • James A. Bourgeois University of California San Francisco
  • Daniel K. Tisi St. Joseph’s Healthcare Hamilton
  • Glen L. Xiong University of California

DOI:

https://doi.org/10.5770/cgj.16.79

Keywords:

delirium, vitamin D, vitamin D insufficiency, acute in-patient, acute care

Abstract

Background

As vitamin D may have a neuroprotective effect, the authors studied the association of biomarkers of vitamin D status and delirium to see if low vitamin D status was common in delirium cases.

Methods

Biochemical measures of vitamin D (25-hydroxyvitamin D [25-OHD]) and calcium metabolism were used in this retrospective cross-sectional analysis of adult in-patients with delirium, admitted at three Canadian academic hospitals from January 2011 to July 2012. Primary outcome was to determine estimates of the prevalence of hypovitaminosis D in this group in whom vitamin D was checked.

Results

Seventy-one (5.8%) out of 1,232 delirium inpatients had their vitamin D measured. Thirty-nine (55%) showed vitamin D insufficiency (25-OHD of 25-75 nmol/L) and 8 (11%) showed vitamin D deficiency (25-OHD < 25 nmol/L). Mean serum 25-OHD levels were lower in males (57.1±7.7 nmol/L) than in females (78.2±6.1 nmol/L), p = .01, even when controlled for age and season. Men were younger than the women (74.4±2.3 vs. 82.4±1.7, p = .005). Mean age was 78.7±1.5 years, and 33 (47%) were male.

Conclusions

Although vitamin D is rarely checked during delirium workup and/or management, high rates of hypovitaminosis D were found to be common in the delirium in-patients in whom it was checked. Larger studies would be needed to estimate the prevalence of hypovitaminosis D in delirium and whether hypovitaminosis D plays a role in the pathogenesis of delirium.

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Published

2013-09-27

How to Cite

1.
Ford J, Hategan A, Bourgeois JA, Tisi DK, Xiong GL. Hypovitaminosis D in Delirium: a Retrospective Cross-sectional Study. Can Geriatr J [Internet]. 2013 Sep. 27 [cited 2022 Jun. 28];16(4):186-91. Available from: https://cgjonline.ca/index.php/cgj/article/view/79

Issue

Section

Original Research